Rejuran vs Sculptra: How They Stimulate Collagen (No S4s Involved)

What Are Rejuran and Sculptra, and How Do They Work?

Rejuran and Sculptra are two injectable treatments designed to naturally stimulate the skin’s collagen production — without being classified as Schedule 4 (S4) medications. Unlike traditional dermal fillers that provide immediate volume, these treatments work more gradually by encouraging the skin to rebuild and rejuvenate itself from within.

Rejuran uses polynucleotides (PN), which are derived from salmon DNA, to support tissue repair, hydration, and elasticity. It’s particularly popular in Korean aesthetic medicine for its gentle, regenerative effects.

Sculptra, on the other hand, contains poly-L-lactic acid (PLLA), a biocompatible synthetic material that works by activating fibroblasts — the skin cells responsible for producing collagen. It’s ideal for improving facial volume and treating areas of skin laxity over time.

You can think of both as collagen-stimulating injectables rather than volume-focused fillers.

How Do These Treatments Support Long-Term Skin Health?

These injectables don’t just provide a quick fix — they are part of a broader trend in preventative aesthetics. Many clients are turning to these options as a way to “collagen bank” — a proactive approach to preserving and supporting collagen production before visible signs of ageing become severe.

• Rejuran improves overall skin texture, hydration, and healing capacity, especially around delicate areas like the under eyes or cheeks.
• Sculptra is effective for treating deeper volume loss, skin laxity, and age-related hollowness, particularly in the mid- and lower-face.

At uSkin Clinics, these treatments are delivered by experienced professionals who follow all AHPRA guidelines — including detailed consultations to assess suitability and outcomes for your individual needs.

If you’re already exploring other rejuvenation techniques like skin boosters or LED phototherapy, these biostimulators can be a powerful complement to your existing treatment plan.

Rejuran vs Sculptra: Which One Is Right for You?

While both Rejuran and Sculptra stimulate collagen, they serve slightly different purposes. Here’s how they typically compare:

You don’t have to choose one without guidance — during your consultation, your clinician can assess your skin’s condition and recommend the most appropriate course of treatment.

Are Rejuran and Sculptra Safe?

Yes — both Rejuran and Sculptra are biocompatible, clinically used in many countries, and not classed as S4 injectables in Australia. This means they can be offered safely under the guidance of a qualified practitioner without breaching regulatory boundaries.

However, you should always book with a trusted clinic to ensure product authenticity and medically appropriate administration. At uSkin Clinics, your safety, comfort, and evidence-based treatment planning come first.

Pairing With Other Skin Rejuvenation Treatments

Because these injectables work gradually, they’re often paired with treatments that boost skin health in the short term. Consider combining Rejuran or Sculptra with:

• Skin needling to stimulate collagen through micro-injury
• Fractionated laser therapy for improving scarring and texture
• Injectable wrinkle treatments to soften dynamic lines while biostimulators work deeper over time
• Ultrasound fat reduction if volume definition is also a goal

Key Takeaways: A Collagen-First Future

• Rejuran is best for improving texture, hydration, and skin repair
• Sculptra helps restore volume, firmness, and long-term collagen
• Both are non-S4 injectables, making them compliant with AHPRA advertising guidelines
• Their popularity is growing as more clients seek natural, long-lasting skin rejuvenation — especially in the context of collagen banking
• uSkin Clinics offers tailored, consultation-based care to help you understand if either is right for your skin

Ready to find out which collagen stimulator might suit your skin goals?
Book a consultation with a clinician today.